Epstein-Barr virus and human cancer

Outstanding researchers from the US and Japan review recent advancements in Epstein-Barr virus (EBV) research. Most individuals harbor EBV in memory B-cells in a latent state, and this virus is linked to various malignancies, including T/NK cell lymphoma, AIDS-associated B-cell lymphoma, gastric carcinoma, and Hodgkin's disease. Advances in molecular biology techniques have enabled the investigation of specific EBV genes involved in maintaining and disrupting latency. The book covers a range of topics, including the enigmatic nature of EBV's plasmid replicon, the replication licensing of EBV oriP minicromosomes, and the activation of the EBV replicative cycle in Akata cells. It discusses two EBV glycoprotein complexes and the enzymes involved in EBV replication. The pathology and molecular pathology of EBV-associated gastric carcinoma are examined, along with its relationship to non-Hodgkin's lymphoma, particularly pyothorax-associated lymphoma. The virological aspects of AIDS lymphoma and the role of EBV in Burkitt's lymphoma are also addressed, highlighting EBV's regulation of c-MYC, apoptosis, and tumorigenicity. Further exploration includes EBV infection in human epithelial cells, characterization of infected epithelial cell lines from gastric cancer tissues, a new animal model for EBV pathogenesis, and the potential of adoptive immunotherapy using EBV-specific cytotoxic T cell lines for treating EBV-associated maligna