Brain Tumor Pathology: Current Diagnostic Hotspots and Pitfalls

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The classification of brain tumors has evolved significantly since the 1926 work of Bailey and Cushing, reflecting advancements in biological research and molecular genetics. Initially based on the resemblance of tumor cells to their origins, classifications provided prognostic insights tied to tumor behavior. The introduction of anaplasia and the development of immunohistochemistry and molecular genetics have refined these classifications, enhancing the accuracy of prognoses and enabling targeted therapeutic approaches by revealing tumor cell origins and pathogenetic mechanisms.