Brain Tumor Pathology: Current Diagnostic Hotspots and Pitfalls

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The classification of brain tumors has evolved significantly since Bailey and Cushing's foundational work in 1926, with tumor types being categorized based on their resemblance to normal cell types and their biological behavior. Initial classifications linked histological features to prognosis, but advancements in anaplasia concepts and molecular genetics have refined these classifications. This evolution has led to more accurate prognoses and improved therapeutic strategies by enhancing the understanding of tumor origins and their pathogenetic mechanisms.