Neuroendocrinology of sex steroids

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This comprehensive work explores the intricate relationships between sex steroids and various physiological processes. It begins with the androgen regulation of neuropeptide gene expression, followed by discussions on steroid modulation of gonadotropin-releasing hormone action in pituitary gonadotropes. The role of steroids and their receptors in brain tumors, particularly meningiomas, is examined, alongside the ultrastructural localization of estrogen-sensitive neurons in the rat forebrain. The text delves into the interplay between sex steroids and opioid peptides, as well as the impact of sex hormone-dependent brain organization on sexual behavior and ovarian function. It also highlights the actions of ovarian steroids on hypothalamic oxytocin and vasopressin expression, and how steroid hormones influence placental production of GnRH and CRF. Further, the book investigates a dopaminergic mechanism for estrogen regulation of hypothalamic β-endorphinergic activity, the involvement of catecholamines and amino acid neurotransmitters in GnRH pulse generation, and the pulsatile pattern of LH secretion relative to the sex steroid environment. It addresses the negative feedback control of gonadotropin secretion by estrogens and androgens across species, and the regulation of corticotrophin-releasing hormone release by steroids, with clinical implications. The work concludes with insights on the control of GnRH and gonadotropin s