Androgenic anabolic steroids, exercise and the heart

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The book is relevant to various biomedical fields, including internal medicine, cardiology, sports medicine, exercise physiology, pharmacology, and tumor research, as well as sports and anti-doping measures. Univ.-Prof. mult. Dr. med. Dr. h. c. mult. Wildor Hollmann highlights that the findings have significant clinical implications, noting that cardiac muscle cell hypertrophy can occur alongside reduced capillarization during physical exercise, potentially leading to an imbalance between oxygen demand and supply, which may trigger an infarct. This research received recognition from the World Federation of Sports Medicine (FIMS) at the 1994 World Congress in Athens. The studies examined the impact of androgenic anabolic steroids and physical exercise on cardiac myocyte hypertrophy and capillarization. Key findings include: ● A three-week training regimen without steroids improved cardiac capillarization (angiogenesis). ● All steroids tested (Dianabol, Oral-Turinabol, Testosterone-propionate) inhibited the exercise-induced increase in capillary supply (angiogenesis inhibition). ● These differences became more pronounced after six weeks. The conclusion drawn is that anabolic steroids and Testosterone-propionate inhibit exercise-induced angiogenesis and negatively affect cardiac capillary supply, resulting in mild myocyte hypertrophy. During intense aerobic exercise, these changes could lead to an imbalance between myocardial ox