Esta serie se adentra en las profundidades del espacio, donde la humanidad establece el primer contacto con inteligencia extraterrestre a través de misteriosas señales. El conocimiento descubierto, descifrado de una computadora extraterrestre, abre una Caja de Pandora de la comprensión humana. La ciencia y la tecnología son llevadas a sus límites, pero también enfrentan una amenaza que podría poner en peligro la propia existencia de la humanidad.
A new radio telescope picks up from the constellation of Andromeda a complex series of signals which prove to be a programme for a giant computer. After the computer is built it begins to relay information from Andromeda. Scientists find themselves possessing knowledge previously unknown to mankind, knowledge that could threaten the security of human life itself.
The Andromeda Breakthrough was a 1962 sequel to the popular BBC TV science fiction serial A for Andromeda again written by Fred Hoyle and John Elliot. Kidnapped by Intel, John Fleming (Peter Halliday) the hero of the first serial, and Andromeda the artificially constructed human (this time played by Susan Hampshire as Julie Christie was unavailable--main reason for the film's failure) are brought to Azaran, a small Middle Eastern country, where a duplicate of the machine he designed has been built by Intel. After many dangers he finds both the reason for the original message having been sent and the means to bring the machine under human control. The complete TV serial survives in the BBC archives and was released, alongside the surviving material from A for Andromeda and various extra features, as part of The Andromeda Anthology DVD set in 2006. Souvenir Press published a book titled more simply Andromeda Breakthrough in 1964. Corgi issued a paperback edition in 1966.