Biochemistry of signal transduction and regulation

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The updated second edition of this bestselling title is now available in softcover. It addresses key concepts in intracellular signal transduction, cellular activity regulation, tumor formation, and apoptosis—topics that are central to Biology and Biological Chemistry. The significance of this field was highlighted by the 1999 Nobel Prize in Physiology awarded to G. Blobel for his work on protein transport regulation. Recent advancements have greatly enhanced our understanding of the molecular mechanisms behind signal transduction, which are now essential knowledge for medicinal chemists, biochemists, and biologists. This book fills a notable gap in textbooks by providing a comprehensive overview of cellular regulation and signal transduction. It begins with gene regulation and enzyme activity, then explores the structure and function of signaling pathways, including various carriers like second messengers, protein kinases, and transmembrane receptors. It also examines critical cellular processes such as cell cycle regulation, oncogenesis, and apoptosis, linking biological phenomena to the biochemical processes at play. The author presents these complex topics with clarity and didactic skill, making it an invaluable resource for understanding regulation and signal transduction.