Asymmetric Synthesis of Bioactive Lactones and the Development of a Catalytic Asymmetric Synthesis of -Aryl Ketones

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The thesis explores advancements in organic chemistry, focusing on the asymmetric synthesis of lactones, crucial components in many natural products. It details a novel methodology developed by the research group that successfully synthesizes natural product analogues with notable biological activity. Additionally, it presents a catalytic asymmetric synthesis of a key structural motif found in various natural products and pharmaceuticals. A significant discovery of dual stereo control is highlighted, enabling the configuration of a new stereo center through a straightforward alteration of the proton source.