Pharmacokinetic-Pharmacodynamic Modeling and Simulation

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Focusing on pharmacokinetic-pharmacodynamic modeling, this book employs a building-block approach, progressing from basic individual models to complex population-level mixed effects models. It emphasizes the interrelationships between different model types, supported by real data from literature and the author's drug development experiences. The analysis utilizes various software tools, including SAS and NONMEM, and highlights the processes of model acceptance and rejection. Ultimately, it aims to create informative models for computer simulations to explore "what-if" scenarios.