Focusing specifically on eye-tracking, this book distinguishes itself by catering to the needs of experimental psychologists through Python programming. It offers unique tools and insights that enhance the understanding and application of eye-tracking technology in psychological research, making it an essential resource for professionals in the field.
Micro RNAs (miRNAs) are known to play an important role in gene expression regulation. Owing to their ever-increasing implications in the control of various biological and pathological processes, miRNAs have now been considered novel biomarkers of various human diseases including, cancer, viral disease, cardiovascular disorders, metabolic disturbances, etc. Unique expression profiles have been associated with specific pathological states. Cardiovascular disease is among the main causes of mortality in developed countries. The pathological process of the heart is associated with altered expression profile of genes that are important for cardiac function. The implications of miRNAs in the pathological process of the cardiovascular system have recently been recognized, and the research on miRNAs in relation to cardiovascular disease is now in rapid progress. The aim of this book is to present updated research on the subject with analyses from published reports. Micro RNAs and Cardiovascular Disease caters to the growing interest and information needs of cardiac clinicians and gene expression researchers.
MicroRNAs (miRNAs), noncoding regulatory mRNAs of 18-25 nucleotides, have become crucial in gene expression regulation, with significant implications in various biological and pathological processes. They are now recognized as novel biomarkers for numerous human diseases, including cancer, viral infections, cardiovascular disorders, and metabolic issues, with specific expression profiles linked to particular conditions. Consequently, miRNA expression profiling has gained importance for both researchers and clinicians. However, traditional methodologies for detecting protein-coding mRNAs cannot be applied to miRNAs due to their smaller size. In recent years, researchers have developed over 30 innovative techniques for miRNA detection and quantification. It is now essential to summarize these methods systematically to enhance understanding and application in miRNA research. Notably, advancements in quantifying circulating miRNAs present exciting opportunities for their use as diagnostic and prognostic biomarkers. A comprehensive resource on this topic could inspire researchers to refine existing techniques and create new methods tailored to emerging applications. This motivation has led to the decision to compile a focused work on miRNA expression detection methods.
MicroRNAs (miRNAs), approximately 22-nucleotide long endogenous noncoding regulatory mRNAs, have become crucial regulators of gene expression across various species, significantly influencing fundamental biological processes and the pathogenesis of human diseases. The advancements in miRNA research have sparked interest in their potential for therapeutic applications. Despite their promise, strategies for effectively utilizing miRNAs in treatment remain unclear. Recent years have seen the emergence of innovative methodologies related to miRNA research, demonstrating their efficacy in manipulating miRNA expression, biogenesis, and function. These advancements provide valuable tools for understanding miRNA roles and developing new therapeutic agents targeting them. The book offers a comprehensive overview of these technologies and their applications in miRNA research and drug design for miRNA-related diseases. It begins with a summary of current knowledge on miRNA biology and their therapeutic potential, followed by an introduction to the concept of miRNA interference (miRNAi) and its prospects. Subsequent chapters detail various miRNAi technologies, including their design, procedures, principles, and applications in basic research, R&D, and clinical therapy, showcasing the state-of-the-art developments in the field.