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This Commentary offers a comprehensive legal analysis of the Convention on the Rights of Persons with Disabilities (CRPD), the primary international human rights instrument focused on individuals with disabilities. It situates the Convention within the broader context of international human rights law and the United Nations' efforts to address inequalities faced by this population. The work begins with a detailed background of the Convention's articles, including the travaux préparatoires, and delves into the substance and interpretation of each provision, highlighting the significance, legal scope, and interrelations with other international legal norms. A unique aspect is the analysis of the Optional Protocol to the Convention. Beyond enriching academic discourse, the Commentary assesses the practical application of the Convention by examining the CRPD Committee's practices and the actions of international and regional human rights bodies in enforcing these rights. It also considers relevant case law from the European Court of Human Rights, the Court of Justice of the European Union, and domestic courts. Contributions from leading scholars and experts make this work an essential resource for lawyers, academics, students, journalists, and NGOs seeking to understand the rights of individuals with disabilities. Additionally, it evaluates the Convention's impact on the legal systems of contracting parties and outlines future d