The book emphasizes the critical need for awareness that tuberculosis (TB) is curable, particularly among those living with HIV. It advocates for a combined approach to treatment, highlighting the necessity of increased resources and funding for both diseases. The message underscores the importance of informing policymakers that addressing TB and HIV should not be seen as mutually exclusive, as providing antiretroviral drugs without adequate TB support can lead to preventable deaths.
TB patients can be offered an HIV test; indeed, research shows that TB patients are more likely to accept HIV testing than the general population. This means that TB programmes can make a major contribution to identifying eligible candidates for ARV treatment. Many people, including those living with HIV, do not know that TB is curable. This is a basic message and one thing that is failing to get through. We should know how to get the message to policy- makers and funders that more drugs are needed for both diseases. It is not "either/or', there is no point providing ARVs only for patients to die of TB for lack of TB resources. Similarly, TB efforts alone are insufficient. HIV/AIDS is dramatically fuelling the TB epidemic in sub-Saharan Africa, where up to 70% of TB patients are co-infected with HIV in some countries. For many years efforts to tackle TB and HIV have been largely separate, despite the overlapping epidemiology. Improved collaboration between TB and HIV/AIDS programmes will lead to more effective control of TB among HIV- infected people and to significant public health gains.
This book will help to determine the features, composition , structure, properties and functions of the genes of Mycobacterium tuberculosis. It will also help to know the impact and relevance of the LCP genes, their functions and role in cell envelope biogenesis. The knowledge of the composition and functions of the genes will be used as a standard to compare and analyze the situation when the LCP gene is deleted from the cell envelope. Hydrophobicity assays, biofilm assays and glycan secretion assays will be performed before and after the deletion of the LCP gene from the cell envelope. The characteristics obtained before and after the deletion of the LCP gene from the cell envelope will be compared. The difference in the results obtained from the characteristics of the cell envelope will be recorded as the effect of the deletion of the LCP genes from the Mycobacterium tuberculosis cell envelope.
Die Untersuchung fokussiert sich auf die Gene von Mycobacterium tuberculosis, insbesondere die LCP-Gene, und deren Rolle in der Biogenese der Zellhülle. Durch verschiedene Tests wie Hydrophobie-Assays und Biofilm-Assays wird die Funktion dieser Gene analysiert, insbesondere vor und nach deren Deletion. Die Ergebnisse zeigen die Auswirkungen der Entfernung des LCP-Gens auf die Eigenschaften der Zellhülle und bieten wertvolle Einblicke in die genetische Zusammensetzung und Funktionalität der Bakterien.