El libro explora el papel del yodo en el metabolismo y su relación con la tiroides y la microbiota. Aborda la tiroiditis y diferentes tipos de hipotiroidismo, proponiendo una revisión de la clasificación de Bastenie al incluir la obesidad en el contexto epigenético de la tiroides. Una perspectiva clínica sobre enfermedades endocrinas.
Este estudio analiza el equilibrio hormonal óptimo en 52 pacientes mediante 92 pruebas de TRH con levotiroxina y su combinación con triyodotironina. Se determina una dosis específica para lograr eutiroidismo, aunque no se observan cambios significativos en colesterol o frecuencia cardíaca en los grupos analizados.
The book explores the historical association between diabetes and myxedema, highlighting its prevalence in females and the elderly due to improved thyroid exploration methods. It discusses the rarity of primary hypothyroidism cases in Africa before 1960 and presents findings of abnormal glucose tolerance in three non-insulin dependent diabetes cases, two of which were diagnosed through classic symptoms. Notably, one case of diabetes preceded the onset of hypothyroidism by five years, discovered incidentally during treatment for an unrelated condition.
The book delves into the evolving role of TRH testing in the context of advanced TSH assay methods, highlighting its limited necessity in most cases. It examines the significance of ultrasensitive tests alongside TRH, noting gaps in current evaluations. The authors investigate the strong correlation between T4 and TSH due to active deiodase enzymes in thyroid cells and explore genetic variability in enzyme activity. A study focuses on patients with treated peripheral hypothyroidism, analyzing TSH responses and determining optimal levothyroxine dosages for effective hormone replacement therapy.