Mohamed Shahen Libros

The book explores the critical role of dengue virus (DENV) transmitted by mosquitoes, responsible for nearly 100 million cases annually. It highlights the incomplete understanding of miRNA expression regulation in DENV-infected patients and suggests that certain human miRNAs may possess antiviral properties. The research indicates that blocking specific antiviral miRNAs with modified antisense oligoribonucleotides can hinder the host's ability to suppress viral replication, shedding light on potential therapeutic approaches against DENV.

The book delves into the critical role of dengue virus (DENV) transmitted by mosquitoes, highlighting its global impact with nearly 100 million cases annually. It explores the interaction between DENV and human miRNAs, focusing on their potential antiviral properties. Research indicates that blocking certain miRNAs can enhance viral replication, while increased viremia correlates with greater disease severity. The authors propose that reducing viremia could mitigate the risk of severe dengue complications, underscoring the importance of understanding immune responses in infected individuals.

Focusing on mosquito control, this book examines the impact of sublethal concentrations of hypochlorite on Culex pipiens larvae. It emphasizes the importance of targeting larvae over adults to achieve effective and environmentally friendly pest management. The research highlights hypochlorite's significant role in managing disease-carrying mosquito vectors, reinforcing its potential as a key component in integrated control programs.

Levels of viremia were linked with increased DENV intensity and proposed that lowering viremia may reduce morbidity and the risk of dengue hemorrhagic fever or dengue shock syndrome. Infected mice by dengue showed increased TNF-a, IFN-g and IL-6 levels, which were recognized as triggers for DENV. We have found that reducing some immune parameters in blood through the use of antiviral treatment significantly decreases pro-inflammatory cytokine levels and increases the concentrations of coagulants factors in the blood of the treated patients. These results suggest that lowering pro-inflammatory cytokine parameters through timely antiviral drug treatment may improve the severity of DF symptoms and perhaps decrease the risk of progression