O livro aborda a malária como um grave problema de saúde pública, afetando 500 milhões de pessoas e causando 2,5 milhões de mortes anuais. Explora o papel do baço e do fígado na resistência à infecção por Plasmodium chabaudi, utilizando um modelo de ratos deficientes em linfotóxina-receptor.
Spleen and liver as effectors against malaria infection
Focusing on the impact of malaria, this book examines the spleen and liver's roles in combating Plasmodium chabaudi infection through studies on lymphotoxin receptor-deficient mice. It highlights the vulnerability of male LT R-/- mice, which, despite castration or vaccination, are more susceptible to infection compared to wild type male C57BL/6 mice. This research provides insights into the immune response mechanisms and potential therapeutic approaches to address malaria's significant public health threat.