Shiva Prasad Kollur Libros

This book is based in the recent advancements in the development of chemical sensors for the detection of mercury and its level of toxicity. Its scope and depth not only covers the recently developed chemosensors, but also introduces various methods of preparation and their mechanism of action towards the detection of mercury. This book explains the harmful impact of mercury on biological systems and the efforts made by the regulating agencies, a decrease in mercury concentration has not been a realized and hence mercury accumulation in the environment remains of utmost concern. Further, designing of novel and efficient probes for recognition and detection of toxic metals in environmental samples has been detailed in the book. Furthermore, occurrence of significant changes in the visible portion of electronic spectra enables detection by the naked eye. Moreover, a brief description has been given on how to overcome the problem of developing efficient probes or sensors bearing fluorescence on-response mechanism that can work effectively in the physiological conditions various methodologies, such as chemo-dosimetric reaction mechanisms for the designing of new luminescent ligands, are being adopted. Overall, this will serve as a useful textbook for the students, scientists or researchers who are studying or working in the field of Environmental chemistry or Biochemistry.

Non-small cell lung cancer (NSCLC) is a prominent subtype of lung carcinoma that accounts for the majority of cancer-related deaths globally, and it is responsible for about 80% to 85% of lung cancers. Mitogen-Activated Protein Kinase (MAPK) signaling pathways are a vital aspect of NSCLC, and have aided in the advancement of therapies for this carcinoma. Targeting the Ras/Raf/MEK/ERK pathway is a promising and alternative method in NSCLC treatment, which is highlighted in this book. The introduction of targeted medicines has revolutionized the treatment of patients with this carcinoma. When combined with current systems biology-driven stratagems, repurposing non-cancer drugs into new therapeutic niches presents a cost-effective and efficient technique with enhancing outcomes for discovering novel pharmacological activity. This book also highlights the successful cutting-edge techniques while focusing on NSCLC targeted therapies. The ultimate challenge will be integrating these repurposed drugs into the therapeutic regimen of patients affected with NSCLC to potentially increase lung cancer cure rates. Shiva Prasad Kollur, Anisha S Jain, Gayatri Vaidya, Poojitha B. Sridara Setty, Shivalingaiah, Ashwini Prasad, Ravindra Veerapur, Veena Malligere Ankegowda, Asad Syed, Ali. H Bhakali, Chandrashekar Srinivasa, Sharanagouda Patil, Chandan Shivamallu