Mohammed Y. Kalimi Libros

This comprehensive collection explores the biological effects and potential therapeutic applications of Dehydroepiandrosterone (DHEA). It begins with a review of DHEA's biological impacts, followed by an examination of its possible anti-aging effects linked to caloric restrictions. The role of DHEA in cytokine dysregulation associated with aging and AIDS is discussed, alongside its influence on the aging immune system. The restoration of immunocompetence in aging and inflammatory diseases through DHEA-3ß-sulfate is also highlighted. The anti-obesity effects of DHEA are explored through clinical studies, mechanisms of action, and its relationship with cardiovascular disease. The implications of DHEA in carcinogenesis, particularly hepatocarcinogenesis, are examined, detailing both the induction of neoplasms and the biochemical changes during neoplastic development. Neuropsychiatric effects and the intricacies of DHEA metabolism in various species are discussed, alongside its role as a precursor of androgens and estrogens. The collection also addresses DHEA's impact on liver function, mitochondrial respiration, and osteoblastic activities. Finally, interactions between DHEA and dexamethasone in lymphocyte proliferation and its relation to stress reactions are presented, providing a holistic view of DHEA's multifaceted roles in health and disease.

This comprehensive exploration of dehydroepiandrosterone (DHEA) delves into its biological significance and potential therapeutic applications. The text begins with foundational insights into DHEA as a precursor steroid, followed by discussions on its role as a neural facilitator, particularly in memory enhancement in both young and aged mice. Clinical studies are presented, highlighting the cognitive effects of DHEA replacement therapy and its implications for Alzheimer's disease, as well as its potential benefits in multiple sclerosis, including effects on fatigue. The book also examines reduced plasma DHEA concentrations in conditions like HIV and Alzheimer's, emphasizing its immune response facilitation against viral and bacterial infections. Further investigations cover DHEA's metabolic regulation by insulin, its impact on obesity, and its effects on mitochondrial respiration and liver function. The epidemiological aspects of DHEAS, especially concerning cardiovascular disease, are analyzed, alongside its influence on cholesterol and lipoproteins. The relationship between DHEA and carcinogenesis, particularly in liver cancer, is scrutinized, revealing its modulatory effects on carcinogenic processes. Overall, the text presents a multifaceted view of DHEA, integrating biochemical mechanisms and clinical implications, while offering insights into its potential as a therapeutic agent across various health conditions.