John A. Hoskins Libros

Respirable crystalline silica can cause silicosis. But does it also cause lung cancer? Although the risk of cancer in silicosis patients is more than double that in people without the disease, experts do not agree on whether silicosis is a necessary pre-cursor for the development of a tumour. In 1997 the International Agency for Research on Cancer (IARC) published a controversial report stating that crystalline silica inhaled in the form of quartz or cristobalite from occupational sources is carcinogenic to humans. The analysis of many epidemiological studies concluded that mining and quarrying have only minor effect in the development of lung cancer, but in manufacturing industries, notably those which entail high temperature processes, the effect is significant. If this report will be universally accepted it could have far-reaching implications for many industries, especially those concerned with the built environment. This issue gives the opinions of various experts, including some who were on the IARC working party, and therefore is an indispensable contribution for those interested in this controversial debate.

Pleural plaques represent the most frequently encountered non-malignant asbestos related condition seen in clinical practice. However, their aetiology is far from clear and diagnosis and differential diagnosis are often difficult. This publication originates from one of the only international meetings held on the subject in many years. Among the aspects thoroughly discussed, it examines the aetiology and pathogenesis of pleural plaques, the clinical pathology and histology, and the incidence of epidemiology of pleural plaques comparing exposed workers with the general population. It also highlights the current interest in pleural plaques which stems from the medico-legal aspects of the condition. This unique source of information will be regularly consulted by those involved in the study of 'fibre toxicology'.