This book is a concise hands-on guide to implementing good laboratory practice standards. Focussing on the practical aspects, this guide introduces the reader to the background, basic principles, operating procedures & OECD standards. It gives invaluable information on how to avoid pitfalls & save precious time & resources.
This volume contains the main papers presented at the 1997 EUROTOX Congress, Århus, Denmark, 24-28 June 1997. Diversification in toxicology is seen as the application of basic science to such diverse areas as man and his environment. The pressing issues which have been dealt with not only include reproductive effects of environmental chemicals ("xenoestrogens"), but also receptor-mediated toxic responses, new frontiers in human and ecological toxicology, chemoprevention of cancer and molecular approaches in toxicological research. The practical and ethical facets of toxicology, e.g. ecotoxicological risk assessment, biomarkers of exposure, complex chemical mixtures as well as animal welfare and the ethics of animal experimentation, are also treated.
Ultraviolet radiation, a component of sunlight, poses potential health hazards due to its genotoxic, carcinogenic, and immunotoxic properties. Its effects include skin cancers, ocular damage, and impaired immunity to infections. Research has shown that UV photons can influence immune system activity through skin interactions, leading to the transformation of normal cells into cancerous ones while also allowing these transformed cells to proliferate by suppressing the immune response. A key area of inquiry is how UV radiation initiates changes in immune function both locally in the skin and systemically in other body areas. Over the past two decades, numerous studies have explored the immunosuppressive effects of UVB radiation in laboratory animals and human volunteers, particularly regarding resistance to tumors and skin-related infections. Investigations have focused on UVB's impact on immune parameters, including contact hypersensitivity, delayed-type hypersensitivity, mixed lymphocyte reactions, antigen presentation, and the function of Langerhans cells. One of the initial studies examined the antigenicity of tumors induced by UVB radiation in mice, highlighting the long-standing interest in understanding UV's role in immune modulation and cancer development.