Tumor necrosis factor

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With the continuing rapid progress in the TNF field, TNF involvement in a range of physiological and pathophysiological phenomena has now been fully ascertained and documented. This volume provides an authoritative overview of the current state of research on all aspects of TNF-a and TNF B and their receptors. The contributions deal with basic chemistry, gene structure, biochemical mechanism of action and cellular responses, as well as the role of the TNFs and their membrane-bound and soluble receptors in various autoimmune, infectious, and malignant cell diseases. Several papers describe the spectacular success rate that has been achieved by clinical approaches using TNF-a in combination with interferon and a chemotherapeutic drug in isolated limb perfusion. Providing a perspective on recent developments in TNF research and considering future directions, this timely book is important reading for all those interested in this fast-moving field.