Research methodologies in human diabetes

This comprehensive work covers a wide range of research methodologies relevant to diabetes and its complications. It begins with the discovery of photocoagulation treatment for diabetic eye disease and progresses through various research methodologies, including blood glucose measurement and the definition of diabetes. The text delves into immunohistochemical methods for studying islet amyloid polypeptide, insulin sensitivity assessments using glucose clamp techniques and minimal models, and methodological issues in dietary studies. Further, it addresses body composition assessment, calorimetry, and techniques for recording blood pressure in diabetic patients. The methodologies extend to evaluating platelet function, endothelial proteins, coagulation factors, and clinical research in diabetic pregnancy. It also explores fetal dysfunction evaluation, exercise protocols, and stress hormone responses in diabetes. The book examines diabetic heart disease, electrophysiological methods for evaluating diabetic neuropathy, and clinical assessments of neuropathy and vascular disease. It discusses renal complications, clinical trials in diabetic renal disease, and methodologies for estimating lipid metabolism and protein metabolism in diabetes. Additionally, it covers pancreas and islet cell transplantation evaluation, survival studies, and the efficacy assessment of oral antidiabetic agents, alongside the biosynthesis of eicosanoids