Critical limb ischemia

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Chronic critical limb ischemia is a leading cause of illness and hospitalization in the western world, with growing interest in recent years. Significant advancements have been made in diagnostic procedures and treatment options, including medical, invasive, and surgical approaches. However, the underlying pathophysiological mechanisms in humans remain unclear. There is a notable focus on microcirculation, hemorheological, hemostatic, and inflammatory changes that may contribute to critical limb ischemia. Further research is essential to assess the prognostic value of microcirculatory investigations and the effectiveness of new therapies. The primary objective is to provide optimal therapy to prevent limb loss and enhance quality of life. It is crucial to evaluate and discuss the various treatment methods, their success rates, and potential complications. This volume addresses the intricate diagnosis and treatment landscape of critical limb ischemia, involving specialists such as angiologists, interventional radiologists, vascular surgeons, plastic surgeons, and diabetologists. Contributions from Belgian and German experts in their respective fields enrich the content, covering epidemiology, pathophysiology, and rational therapy. Their collaboration has been instrumental in producing this comprehensive resource.