Inhibitors of cell growth

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The containment of cell growth is essential for the homeostatic regulation of metazoans, and significant advancements have been made in understanding this process. Much of the knowledge stems from identifying molecules with positive and negative regulatory effects on cell proliferation, with a focus on these molecules. Some are already used therapeutically, while others show promise for future applications. This volume illustrates various approaches to this understanding. Control of cell growth is also crucial for comprehending phylogenetic and ontogenetic development. It raises questions about why organisms have evolved complex mechanisms to regulate their size and organ dimensions, how different cells arise—some for renewal and repair, others for specialized functions in a postmitotic state, and germinal cells awaiting signals to initiate new organisms. However, there is a significant gap in knowledge regarding the structural characteristics of cells and how these relate to function. The ability of structure to alter responses to identical signals is not well understood. While positive and negative growth regulators may be conserved, the structural organization of genetic material and other cellular components varies greatly, significantly influencing cell proliferation behavior.