Occlusive arterial disease

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In this fourth volume of the prestigious "New Horizons" Series, key aspects of hypertension, diabetes mellitus, and dyslipidemias are explored, focusing on their interplay and the development of occlusive arterial disease. Scholarly chapters by renowned scientists and clinicians address practical issues and unresolved problems from clinical, cellular, molecular, and genetic perspectives. Topics on hypertension cover future treatment challenges, large artery mechanical function as a treatment target, the renin-angiotensin system's role in blood pressure genetics, hypertension and cardiovascular risk in youth, vascular tone regulation, and endothelial function developments. The relationship between diabetes mellitus and occlusive arterial disease is critically examined, including recent research, advanced glycosylation end-products in complications, insulin resistance, dyslipidemia in syndrome X, diabetes genetics, oxidative stress implications, and metabolic syndrome controversies. Dyslipidemia chapters delve into HDL and cardiovascular risk, molecular genetics insights, gene expression in coronary artery disease, atherosclerotic plaque destabilization mechanisms, lipoprotein metabolism, and drug action on lipoprotein metabolism. Additional discussions include atherosclerosis causes, thrombosis's role in arterial disease, and the infection debate in atherogenesis. This volume offers valuable insights for cardiologists, clinicia