Proteomics in nephrology

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The discipline of proteomics has rapidly grown and holds significant future potential, offering insights across various fields. By studying proteins on a genomic scale, researchers can analyze a large number simultaneously and gain information about post-translational modifications and protein functions that genomic analysis cannot provide. This knowledge enhances our understanding of renal physiology and pathophysiology, aids in identifying disease biomarkers, and supports the development of targeted therapies. This publication is the first to apply proteomics specifically to nephrology, providing an overview of the discipline, including its scope, advantages, and limitations. It reviews key proteomic techniques such as sample preparation, two-dimensional gel electrophoresis, mass spectrometry, expression and quantitative proteomics, bioinformatics, and clinical applications. The final section presents examples of proteomics in nephrology, addressing topics like nephrotoxicity, sodium transport, diabetic nephropathy, renal Fanconi syndrome, IgA nephropathy, podocyte and mesangial cell physiology, hypertension, urological malignancies, and dialysis. It concludes with a discussion on biomarker and drug discovery in glomerular diseases. Authored by experts in proteomics and nephrology, this book is essential for students, residents, fellows, scientists, nephrologists, and health professionals interested in research and clinical