Sildenafil

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This landmark drug has become the definitive therapy for erectile dysfunction (ED) following significant advancements in nitric oxide (NO) physiology and pharmacology. This reference book presents the latest information, including ongoing research on NO as an endothelium-derived relaxing factor (EDRF) and as a neurotransmitter for erectile tissue in mammals. As one of the first oral phosphodiesterase-5 (PDE5) inhibitors, this drug successfully transitioned from basic NO research to routine clinical use. The volume explores various applications for both men and women, addressing the critical medical need for drug improvements in a competitive research landscape. Readers will gain insights into clinical resistance to treatment and strategies to mitigate failure rates. Individual chapters, authored by leading experts, cover clinical use, pharmacokinetics, pharmacodynamics, biochemistry, and cultural aspects. This comprehensive resource offers professionals in the pharmaceutical industry, physicians, biochemists, chemists, and pharmacologists an up-to-date knowledge base on current research activities and an excellent overview for further exploration of this compound class and its cultural significance.