Bone Morphogenetic Proteins: Regeneration of Bone and Beyond

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Since the discovery of bone morphogenetic proteins (BMPs) over 15 years ago, there has been a remarkable surge in both basic scientific research and clinical applications worldwide. BMPs have demonstrated significant efficacy in crucial developmental processes and organ regeneration, including bone, kidney, brain, liver, and heart, making them a focal point of scientific inquiry. This volume covers their roles in development, biology, signal transduction, kidney regeneration, central nervous system functions, craniofacial reconstruction, joint and cartilage repair, long bone non-unions, acute fractures, and spinal fusion, with insights from leading experts. Notably, it also explores BMPs' involvement in carcinogenesis, providing a rationale for their potential use in treating bone tumors. The positive outcomes from the safe application of BMPs in over 10,000 patients with skeletal malformations have opened new avenues for their use. The next significant challenge lies in utilizing BMPs for regenerating articular cartilage defects and aiding patients with acute and chronic renal failure. The volume editors express gratitude to all authors for their prompt contributions, ensuring the content remains current for those interested in regenerative medicine.