New Aspects of Hypertrophic Cardiomyopathy

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This comprehensive examination delves into hypertrophy and hyperplasia, focusing on the development and regression of right ventricular hypertrophy, alongside biochemical and morphological aspects. It explores myocardial structure and left ventricular function in various conditions, including hypertrophic obstructive cardiomyopathy (HOCM) and dilative cardiomyopathy. The text presents quantitative analyses of endomyocardial biopsies, revealing evidence of muscle fiber and myocyte hyperplasia in hypertrophic cardiomyopathy and other related disorders. It discusses the variability and reproducibility of morphologic findings in biopsies, correlating these with clinical parameters and the effects of medical therapy on myocardial hypertrophy. Diagnostic techniques such as radionuclide ventriculography and cardiac computed tomography are highlighted, examining their roles in assessing cardiac function. The annotation also addresses the dynamic obstruction to left ventricular outflow in HOCM and the influence of various treatments, including verapamil and propranolol, on cardiac function. Long-term outcomes of medical and surgical therapies are evaluated, alongside programmed electrical stimulation in patients. Additionally, it touches on experimental findings in other forms of cardiomyopathy, including capillary density in dilated cardiomyopathy and treatment comparisons in familial forms. Overall, the text provides a detailed over