Asymmetric metal catalysis in enantioselective domino reactions

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This book introduces an innovative tool for synthesizing complex chiral structures in a single step. It compiles significant advancements in enantioselective one-, two-, and multicomponent domino reactions using chiral metal catalysts, covering literature since 2006. The text illustrates how these metal-catalyzed processes facilitate the development of diverse one-pot asymmetric domino reactions, enabling the generation of intricate products from simple materials. Adhering to Tietze's definition, it encompasses single-, two-, and multicomponent transformations. The content is organized into twelve chapters, focusing on various metal-catalyzed domino reactions involving copper, palladium, rhodium, silver, and others. Each chapter is structured into sections on one- and two-component reactions, followed by three-component processes, categorized by the nature of the reactions. Selected applications of these methodologies for synthesizing natural and biologically active products are included. The book showcases the combination of asymmetric metal catalysis with domino reactions, emphasizing high molecular complexity and enantioselectivity. It also highlights applications in the total synthesis of natural products, pharmaceuticals, and agrochemicals. Written by a leading expert, it will interest synthetic, organic, medicinal, and catalytic chemists in academia and R&D.