Chemical biology of neurodegeneration

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This book bridges the gap between the chemistry of small molecule neuromodulators and the complexities of neurodegenerative disorders. Written by an experienced neurochemist, it focuses on key molecular actors in these disorders, emphasizing structural aspects and modes of action. Drawing on recent data regarding enzyme structure, function, and inhibitor design, it examines the six most crucial neurotransmitter systems along with their enzymes and receptors from a biochemical perspective. The text also addresses protein misfolding and aggregation in the brain. A comprehensive survey of various therapeutic agents that modulate essential brain processes is included, detailing their chemical synthesis and modes of action in both model systems and patients. The content is divided into two parts: the first introduces neurotransmitter systems, providing a general overview of synapses and identifying therapeutic targets for central nervous system disorders. The second part delves into the molecular and chemical aspects of neurodegeneration, covering neurotransmitter metabolism, enzyme processing, protein misfolding, and therapeutic agents. Utilizing an interdisciplinary approach, the book emphasizes the chemistry of small molecule modulators as potential drug leads and covers six key neurotransmitter systems: dopaminergic, noradrenergic, serotonergic, cholinergic, GABAergic, and glutamatergic. This resource is invaluable for medic