Advanced chemical biology

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This text is organized around the central dogma of life, progressing from genes to proteins and higher-order cellular structures, while covering core application areas such as imaging, chemical genetics, activity-based protein profiling, and natural product discovery and biosynthesis. Advanced topics in microbiology, developmental biology, and neurobiology are addressed in separate sections. Each chapter features a consistent style, beginning with a historical introduction, followed by underlying concepts and recent practical examples. The content is divided into core and supplemental chapters, allowing for flexible teaching in one- or two-semester courses. Authored by experts from leading scientific institutions, it includes detailed discussions on various topics: DNA function, synthesis, and engineering; chemical approaches to genome integrity; RNA function and probing; transcription regulation; genome engineering; peptide/protein synthesis; directed evolution; cellular metabolism; lipids; protein modifications; glycobiology; protein modification techniques; genetic code expansion; bio-orthogonal chemistry; and cellular imaging. With its comprehensive scope and emphasis on practical application, this work serves as an excellent resource for newcomers to the field, providing guidance on the diverse methods and strategies available in chemical biology. It features a Foreword by Nobel Laureate Carolyn Bertozzi.