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Parámetros
- 152 páginas
- 6 horas de lectura
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Focusing on the synthesis and evaluation of stable lipoxin analogues, the thesis presents groundbreaking work by Colm Duffy, who successfully created a pyridine-containing LXA4 analogue in enantiomerically pure form for the first time. The study reveals that both epimers suppress key cytokines linked to inflammatory diseases, with the (R)-epimer demonstrating superior efficacy. Additionally, Duffy developed a thiophene-containing analogue, showing promising biological activity, which has sparked further research into synthesizing more heteroaromatic analogues for evaluation.
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Heteroaromatic Lipoxin A4 Analogues, Colm Duffy
- Idioma
- Publicado en
- 2012
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- Subtítulo
- Synthesis and Biological Evaluation
- Idioma
- Inglés
- Autores
- Colm Duffy
- Editorial
- Springer Berlin Heidelberg
- Publicado en
- 2012
- Formato
- Tapa dura
- Páginas
- 152
- ISBN13
- 9783642246319
- Serie
- Springer Theses
- Etiquetas
- No ficción
- Descripción
- Focusing on the synthesis and evaluation of stable lipoxin analogues, the thesis presents groundbreaking work by Colm Duffy, who successfully created a pyridine-containing LXA4 analogue in enantiomerically pure form for the first time. The study reveals that both epimers suppress key cytokines linked to inflammatory diseases, with the (R)-epimer demonstrating superior efficacy. Additionally, Duffy developed a thiophene-containing analogue, showing promising biological activity, which has sparked further research into synthesizing more heteroaromatic analogues for evaluation.