Principles of neural science

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Since the first edition of Principles of Neural Science, four significant advances have prompted an earlier revision. First, recombinant DNA and monoclonal antibody techniques have opened new avenues for solving neurobiological problems. Second, patch clamping has enabled researchers to investigate conformational changes in single ion channels within intact membranes. The third advance involves revolutionary nerve cell labeling and tracing methods, which have clarified previously obscure relationships between brain structure and behavior. Lastly, new noninvasive imaging techniques allow for the study of anatomical structures in the living human brain, facilitating an integrated approach to teaching neuroanatomy alongside other areas of neural science. This second edition serves as an introductory text for students in biology, behavior, and medicine, featuring a more comprehensive treatment of neuroanatomy. The growth of functional neuroanatomy allows for a detailed description of the principles underlying the anatomical structure of brain systems, linking physiology with their roles in behavior and disease. The textbook aims to convey the excitement surrounding cell- and molecular-biological techniques in studying the nervous system, brain development, and behavior control, while also addressing neurological and behavioral disorders that are scientifically instructive and clinically significant.