A Mathematical Model of the Human Sleep Wake System

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The book presents a comprehensive model of the human sleep/wake system, developed from known neuronal groups and their projections. It distinguishes between slow homeostatic regulation and faster dynamics during sleep, notably omitting periodic forcing terms found in other models, indicating that sleep/wake is independent of diurnal stimuli. The model undergoes linearized stability analysis and is validated with experimental data from both normal and orexin knockout sleep-wake systems, ensuring its physiological relevance.