Ligand Binding in the Transmembrane Region

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Focusing on the identification and optimization of non-competitive antagonists for group I metabotropic glutamate receptors (mGluRs), this work by Tobias Noeske explores innovative strategies that promote a diverse range of chemotypes. It details the development of pharmacological assays to assess compound bioactivity and the use of computer-aided methods to identify potential candidates. The research emphasizes optimizing promising molecules for bioactivity and selectivity, making it a valuable resource for scientists in early-stage drug discovery and computer-aided drug design.