Synthesis of Pyran Derivatives and Their Biological Activity

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The book presents a pioneering approach to synthesizing ethyl 6-amino-5-cyano-2-methyl-4H-pyran-3-carboxylate derivatives using water and ethanol as solvents, with urea as a novel catalyst. It highlights the efficiency of this method, achieving high yields in a short reaction time. Additionally, the findings indicate that aromatic aldehydes with electron-withdrawing groups yield better results and require less time compared to those with electron-donating groups, showcasing the significance of substituent effects in the synthesis process.