Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins

Más información sobre el libro

Focusing on the therapeutic potential of Au (I, III) complexes, the book investigates their selective inhibition of zinc finger proteins (ZnFs), particularly targeting the HIV-1 nucleocapsid protein and the human transcription factor Sp1. Innovative techniques such as Travelling-Wave Ion Mobility coupled with Mass Spectrometry and X-ray Absorption Spectroscopy are employed to elucidate the coordination sphere of gold adducts. Additionally, the organometallic compound [Au (bnpy)Cl2] is assessed for its ability to inhibit ZnFs through C-S coupling, revealing promising insights for future treatments.