Monographs in Epidemiology and Biostatistics - 26: Methods in Observational Epidemiology

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This updated edition provides a comprehensive overview of the design, conduct, analysis, and interpretation of non-experimental studies on infectious and non-infectious diseases. It reflects significant advancements in epidemiology over the past decade, including the increased availability of computerized health records and a deeper understanding of epidemiologic concepts. The text addresses modifications in study designs, such as nested case-control and case-cohort studies, and incorporates the use of biological markers for exposure and disease susceptibility. The authors detail various observational study types, including cohort, case-control, and cross-sectional studies, presenting statistical procedures in accessible language. Key topics such as sample size estimation, sampling, and measurement error are thoroughly discussed. Each chapter has been updated, with some expanded to include new data sources and methodologies. Notably, Chapter 3 now features additional data sources, while Chapter 5 discusses modern study design modifications. Chapter 15 has been broadened to cover measurement in studies of the elderly and biological markers, reflecting recent research trends. The authors aim to make complex statistical methods understandable for readers with limited mathematical backgrounds. While the book targets those with introductory knowledge in epidemiology and biostatistics, it ensures that all readers can grasp the ra