Bone morphogenetic proteins: regeneration of bone and beyond

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Since the discovery of bone morphogenetic proteins (BMPs) over 15 years ago, there has been a remarkable surge in both basic scientific findings and clinical applications globally. BMPs play a crucial role in various developmental processes and organ regeneration, including bone, kidney, brain, liver, and heart, making them a focal point of scientific research. This volume covers their involvement in development, biology, signal transduction, kidney regeneration, central nervous system functions, craniofacial reconstruction, joint and cartilage repair, long bone non-unions, acute fractures, and spinal fusion, with insights from leading experts. For the first time, the role of BMPs in carcinogenesis is examined, offering a rationale for their application in treating bone tumors. The successful treatment of over 10,000 patients with BMPs for skeletal malformations has generated optimism and opened new avenues for their use. The next significant challenge is using BMPs to regenerate articular cartilage defects and assist patients with acute and chronic renal failure. The volume editors express gratitude to all authors for their prompt contributions, ensuring the content remains current for those interested in regenerative medicine.