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Colm Duffy's thesis explores stable lipoxin analogues' chemistry and biology. He synthesized a pyridine-containing LXA4 analogue in enantiomerically pure form and found that both epimers suppress key cytokines in inflammatory diseases, with the (R)-epimer being the most effective. He also developed a thiophene-containing analogue with notable biological activity, inspiring further research.
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Heteroaromatic Lipoxin A4 Analogues, Colm Duffy
- Idioma
- Publicado en
- 2014
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- Subtítulo
- Synthesis and Biological Evaluation
- Idioma
- Inglés
- Autores
- Colm Duffy
- Editorial
- Springer, Berlin
- Publicado en
- 2014
- Formato
- Tapa blanda
- Páginas
- 152
- ISBN13
- 9783642438929
- Serie
- Springer Theses
- Etiquetas
- No ficción
- Descripción
- Colm Duffy's thesis explores stable lipoxin analogues' chemistry and biology. He synthesized a pyridine-containing LXA4 analogue in enantiomerically pure form and found that both epimers suppress key cytokines in inflammatory diseases, with the (R)-epimer being the most effective. He also developed a thiophene-containing analogue with notable biological activity, inspiring further research.