Rheumatoid disease pathophysiology molecular mechanisms

Prolonged fever, lasting over five days without a clear cause, is primarily linked to infectious origins in infants and young children, with viral infections being the most common. Other notable causes include Mycoplasma pneumoniae infections, urinary tract infections, and otitis media. Kawasaki disease is the primary inflammatory cause, while systemic juvenile rheumatoid arthritis is less frequent. Diagnosis typically relies on a focused clinical evaluation and targeted laboratory or imaging tests.